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Updated: Jul 4, 2025

A Multi-detection Assay for Malaria Transmitting Mosquitoes
Published on: February 28, 2015
A single locus determines praziquantel response in Schistosoma mansoni
Frédéric D Chevalier1, Winka Le Clec'h1, Matthew Berriman2
1Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Abstract:
We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci situated on chromosomes 2 and 3. We reanalyzed this GWAS using the latest (version 10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that PZQ response is monogenic and demonstrates the importance of high-quality genomic information.

