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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Cutaneous malignancies in chronic lymphocytic leukemia.

Catherine Zilberg1,2, Angela L Ferguson3, James G Lyons1,3

  • 1Department of Dermatology, The University of Sydney at Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

The Journal of Dermatology
|January 31, 2024
PubMed
Summary

Patients with chronic lymphocytic leukemia (CLL) face a higher risk of developing worse skin cancers due to immune system deficiencies. Regular dermatologic follow-up is crucial for this high-risk group.

Keywords:
chronic B-cellleukemiamelanomaskin neoplasmssquamous cell

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Area of Science:

  • Oncology and Immunology
  • Dermatology

Background:

  • Chronic lymphocytic leukemia (CLL) is a prevalent lymphoid malignancy.
  • CLL patients exhibit increased susceptibility to cutaneous malignancies like melanoma and keratinocyte cancers (KC).
  • Immunodeficiency in CLL impacts both adaptive and innate immunity, contributing to skin cancer development.

Purpose of the Study:

  • To review the interplay of genetics, immunity, and pathogens in skin tumors within CLL patients.
  • To compare skin tumor biology in CLL with other chronic hematological malignancies.
  • To emphasize the importance of dermatologic awareness and follow-up for CLL patients.

Main Methods:

  • Literature review focusing on CLL, cutaneous malignancies, and immune system interactions.
  • Comparative analysis of skin tumor microenvironment in CLL versus other hematological malignancies.

Main Results:

  • CLL is linked to poorer clinical outcomes for associated skin cancers.
  • Immune dysfunction in CLL patients is a key factor in increased skin cancer prevalence.
  • Genetics, immunity, and pathogens significantly influence skin tumor biology in CLL.

Conclusions:

  • Dermatologists must recognize the heightened risk of cutaneous malignancies in CLL patients.
  • CLL patients constitute a high-risk population requiring diligent dermatologic surveillance.
  • Understanding the complex interplay of factors is vital for managing skin health in CLL.