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Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

David Sánchez-Marín1, Macrina Beatriz Silva-Cázares2, Fany Iris Porras-Reyes3

  • 1Posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04360, México.

Genes & Diseases
|January 31, 2024
PubMed

Insights

Long non-coding RNAs (lncRNAs) can fuse with other genes, potentially driving cancer. This review explores identified lncRNA fusions, their functions, and therapeutic potential in oncology.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of cellular functions.
  • Dysregulated lncRNAs are implicated in cancer development and progression.
  • Gene fusions, previously thought to involve mainly protein-coding genes, can also involve lncRNAs.

Purpose of the Study:

  • To review identified lncRNA fusions.
  • To investigate the functional significance of lncRNA fusions in cancer.
  • To explore the potential of lncRNA fusions as cancer biomarkers and therapeutic targets.

Main Methods:

  • Literature review of identified lncRNA fusions.
  • Analysis of associated biological functions and tumor phenotypes.
  • Discussion of challenges and future directions in lncRNA fusion research.

Main Results:

  • lncRNAs can form gene fusions with mRNAs and other lncRNAs.
  • The biological significance of lncRNA fusions in cancer is an emerging area of research.
  • Several lncRNA fusions show potential as biomarkers or therapeutic targets.

Conclusions:

  • lncRNA fusions represent a novel mechanism in cancer biology.
  • Further research is needed to elucidate their role in tumorigenesis.
  • lncRNA fusions offer a promising future therapeutic window in cancer treatment.
Keywords:
CancerGene fusionsTherapylncRNAsncRNAs

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