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NHCs silver complexes as potential antimicrobial agents.

Stephen R Isbel1, Siddappa A Patil1,2, Alejandro Bugarin1

  • 1Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, FL 33965, USA.

Inorganica Chimica Acta
|January 31, 2024
PubMed
Summary
This summary is machine-generated.

N-heterocyclic carbenes (NHCs) form silver complexes with enhanced antimicrobial activity. This review summarizes NHC-silver derivatives reported between 2006 and 2023, highlighting their antimicrobial potential.

Keywords:
Antimicrobial activityBioactive compoundsNHCSilver acetateSilver halides

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Area of Science:

  • Materials Science
  • Medicinal Chemistry
  • Inorganic Chemistry

Background:

  • N-heterocyclic carbenes (NHCs) are versatile organic ligands.
  • NHCs form stable complexes with metal ions, notably silver.
  • Silver complexes often exhibit superior antimicrobial properties compared to silver alone.

Purpose of the Study:

  • To review reported NHC-silver derivatives with antimicrobial activity.
  • To consolidate findings on NHC-based silver compounds from 2006 to 2023.

Main Methods:

  • Literature search of scientific articles.
  • Focus on NHC-silver complexes (acetates, chlorides, bromides, iodides).
  • Analysis of reported antimicrobial activities.

Main Results:

  • NHC-silver complexes demonstrate significant antimicrobial efficacy.
  • Various NHC-silver derivatives (acetates, chlorides, bromides, iodides) show promise.
  • The field has seen consistent research from 2006 to 2023.

Conclusions:

  • NHC-silver complexes represent a promising class of antimicrobial agents.
  • Further research into NHC-silver derivatives could lead to novel therapeutic applications.
  • The synergistic effect of NHCs and silver enhances antimicrobial action.