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Updated: Jul 10, 2026
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Computerized Adaptive Testing System of Functional Assessment of Stroke
Published on: January 7, 2019
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A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional
Alberto Zingaro1,2,3, Zan Ahmad1,4, Eugene Kholmovski1,5
1ADVANCE, Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, 3400 N. Charles St., 21218, Baltimore, MD, USA.
Biorxiv : the Preprint Server for Biology
|January 31, 2024
Summary
Integrating cardiac magnetic resonance (CMR) and computational fluid dynamics (CFD) offers personalized stroke risk assessment. Normalizing hemodynamic features by stroke volume, not ejection fraction, significantly distinguishes stroke patients.
Area of Science:
- Cardiovascular Medicine
- Biomedical Engineering
- Medical Imaging
Background:
- Stroke is a leading cause of death and disability globally, necessitating improved risk prediction.
- Existing stroke risk scores, such as CHA2DS2-VASc, may lack personalized predictive power.
- Cardiac dynamics play a crucial role in stroke etiology, yet are not fully integrated into risk models.
Conclusions:
- The synergistic fusion of CMR-derived functional data and patient-specific CFD simulations provides a personalized and mechanistic understanding of stroke risk.
- Motion-informed, personalized risk assessments are crucial for improved stroke prediction.
- This novel framework enhances stroke risk stratification, offering valuable clinical implications.
