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Related Experiment Video

Updated: May 3, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Circulating immune complexes in pulmonary eosinophilic granuloma.

T E King, M I Schwarz, R E Dreisin

    Annals of Internal Medicine
    |September 1, 1979
    PubMed
    Summary

    Circulating immune complexes are elevated in most patients with active pulmonary eosinophilic granuloma, suggesting their role in disease pathogenesis.

    Area of Science:

    • Immunology
    • Pulmonology
    • Pathology

    Background:

    • Pulmonary eosinophilic granuloma is a rare lung disease.
    • The role of immune complexes in its pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the presence and significance of circulating immune complexes in patients with pulmonary eosinophilic granuloma.

    Main Methods:

    • Serum analysis for circulating immune complexes.
    • Correlation with pulmonary histopathology and immunofluorescence findings.
    • Light microscopy and immunofluorescence of lung tissue.

    Main Results:

    • Elevated circulating immune complexes were found in 5 out of 6 patients.
    • All patients with elevated complexes had active cellular histology and IgG/C3 deposition in lung tissue.

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  • One patient without detectable immune complexes showed fibrotic changes and no immune deposition.

    • Conclusions:

    • Circulating immune complex-like activity is associated with active pulmonary eosinophilic granuloma.
    • Immune complex formation or deposition may play a role in the disease's pathogenesis.