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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
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Nanosuspension-Based Drug Delivery Systems for Topical Applications
Mohamed Mahmud E Aldeeb1,2, Gofarana Wilar3, Cecep Suhandi1
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
International Journal of Nanomedicine
|January 31, 2024
Summary
Nanosuspensions, particularly nanocrystals, show promise for topical drug delivery by enhancing skin adhesion and solubility. This approach improves cutaneous bioavailability for poorly soluble drugs, advancing topical formulations.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Dermatology
Background:
- Hydrophobic drugs often face bioavailability challenges due to poor solubility.
- Nanosuspensions offer a strategy to overcome these solubility limitations.
- Topical drug delivery, including mucosal and dermal applications, is an evolving area of interest.
Purpose of the Study:
- To provide a comprehensive overview of nanosuspensions for topical applications.
- To explore the potential of nanocrystals for enhancing cutaneous drug delivery.
- To assess the impact of nanosuspensions on skin permeability and drug accumulation.
Main Methods:
- Review of existing literature on nanosuspensions for topical use.
- Analysis of formulation techniques for nanosuspensions.
- Examination of studies investigating skin permeation and drug accumulation.
Main Results:
- Nanosuspensions, especially nanocrystals, enhance saturation solubility and dissolution rates.
- Nanocrystals demonstrate increased skin adhesiveness, improving cutaneous distribution.
- Evidence suggests nanosuspensions can enhance cutaneous bioavailability for low to medium solubility drugs.
Conclusions:
- Nanosuspension technology, particularly nanocrystals, holds significant potential for topical drug delivery.
- Further research is needed to address limitations such as sample size and explore historical perspectives.
- The versatility of nanosuspensions supports their continued investigation for advanced topical formulations.
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