Molecular Selectivity in the Binding of Alkali Metals, Alkaline Earth Metals, First-Row Transition Metals, and
Emmanuel Nkyaagye1, Miranda N Limbach1, Thanh D Do1
1Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996, United States.
Abstract:
Beauvericin (BEA) and enniatins (ENN) are cyclic hexadepsipeptide mycotoxins known for their ionophoric activities across cell membranes. While their ability to selectively bind alkali ions to form binary complexes has been studied, their interaction with multivalent metal ions to form higher-order complexes remains less explored. We report the unique characteristics of the 1:2, M:BEA or ENN complexes with monovalent, divalent, and trivalent metal ions. A thorough IMS-MS analysis underscores the substantial interplay among ionic radii, coordination numbers, and their impact on conformational selection within higher-order complexes that is pertinent to ion transport. Transition metals offer insights into the effects of ion radii and ligand side chains on conformational selection, while lanthanide complexes enable a direct evaluation of coordination chemistry. An intriguing finding concerning the lanthanide complexes involves an unexpected C-H bond activation, wherein water ligands may catalyze the deprotonation of the cyclic peptides.
More Related Videos
Related Concept Videos
Ligand Binding Sites
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Drug-Receptor Bonds
In...
Complexation Equilibria: Factors Influencing Stability of Complexes
Ligand Binding and Linkage
Complexation Equilibria: The Chelate Effect


