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Related Experiment Videos

Spindle coma in viral encephalitis.

N Dadmehr, A Pakalnis, M E Drake

    Clinical EEG (Electroencephalography)
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Electroencephalogram (EEG) spindle coma patterns can evolve with clinical improvement, even in cases of herpes simplex virus (HSV) encephalitis. This highlights the diverse presentations and potential infectious causes of this EEG pattern.

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    Area of Science:

    • Neurology
    • Neurophysiology
    • Infectious Diseases

    Background:

    • The spindle coma pattern on electroencephalogram (EEG) is a recognized phenomenon associated with various conditions, including intoxication and cerebral lesions.
    • Its occurrence in infectious etiologies like herpes simplex virus (HSV) encephalitis, particularly with evolving patterns, is less commonly reported.

    Observation:

    • A patient presented with an EEG demonstrating the spindle coma pattern, which subsequently normalized in conjunction with clinical recovery.
    • Initial focal asymmetry on EEG suggested a focal cerebral abnormality, contributing to the suspicion of HSV encephalitis despite a lack of definitive radiologic or pathologic evidence.

    Findings:

    • The observed clinical and EEG evolution underscores the heterogeneity of the spindle coma pattern.

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  • Partially damaged cerebral cortex can exhibit spindle activity, a phenomenon documented in diverse cerebral lesions and toxic exposures.
  • The case suggests a potential, though previously unreported, association between HSV encephalitis and the spindle coma pattern.

    • Implications:

    • The findings suggest that infectious etiologies, such as HSV encephalitis, should be considered in the differential diagnosis of patients presenting with the spindle coma pattern, especially when accompanied by focal EEG abnormalities.
    • The pathophysiology may involve aberrant cortical responses to normal subcortical input, as seen in other conditions causing spindle coma.
    • Further investigation into infectious causes of the spindle coma pattern is warranted.