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Regional differences in electroactive response of the sclera.
Hamed Hatami-Marbini1, Jafar Arash Mehr1
1Computational Biomechanics Research Laboratory, Mechanical and Industrial Engineering Department, University of Illinois at Chicago, Chicago, IL, USA.
Summary
The sclera
Area of Science:
- Biomaterials Science
- Ocular Biomechanics
- Electroactive Polymers
Background:
- The sclera, the eye's protective outer layer, exhibits electroactive properties.
- Understanding scleral electroactive response is crucial for ocular device development.
Purpose of the Study:
- To investigate regional variations in the electroactive response of porcine sclera.
- To analyze how clamping configuration affects meridional scleral strips' electroactivity.
Main Methods:
- Excised porcine scleral strips from various meridional and circumferential locations.
- Measured electroactive bending response under 10V and 15V in saline solution.
- Tested meridional samples with anterior and posterior clamping configurations.
Main Results:
- Scleral electroactive deformation increased with higher applied voltage.
- Meridional strips showed greater electroactivity when anteriorly clamped.
- Circumferential samples' electroactivity varied significantly by region, with posterior samples being most responsive.
Conclusions:
- Scleral electroactive response exhibits significant regional differences.
- Variations in biochemical and biomechanical properties likely underlie regional electroactivity.
- Findings inform the design of electroactive ocular devices.
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