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Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
Published on: May 12, 2020
[A case of fungal keratitis caused by Petriella setifera infection]
1Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Jinan 250021, China.
Abstract:
The patient, a 66-year-old male, suffered from redness, blurred vision, photophobia, and tearing in the right eye after being injured by a wooden board. Anti-inflammatory treatment showed poor effectiveness. A 4 mm × 4 mm infiltrate with white deposits on the surface was observed in the central cornea of the right eye. Microscopic examination of corneal scrapings, fungal culture, and in vivo confocal microscopy all indicated fungal infection. The isolated strain was identified as Scedosporium apiospermum through microscopic morphology and confirmed as Petriella setifera by gene sequencing. The patient received corneal debridement combined with routine anti-inflammatory and antifungal treatment in the outpatient clinic. During the follow-up period, the condition continued to improve. Slit lamp examination at the revisit 40 days after the initial diagnosis revealed thinning of the corneal stroma, basic healing of the epithelium, and an increase in uncorrected visual acuity from 0.3 to 0.6.
Insights
A corneal fungal infection caused by Scedosporium apiospermum (Petriella setifera) was successfully treated in a 66-year-old male. Treatment involved corneal debridement and antifungal therapy, leading to improved vision.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Corneal fungal infections can cause significant vision impairment.
- Traumatic eye injuries increase the risk of microbial keratitis.
- Scedosporium apiospermum, now identified as Petriella setifera, is an opportunistic fungal pathogen.
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