Related Experiment Video

Updated: Jul 4, 2025

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
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ZNF148 inhibits HBV replication by downregulating RXRα transcription

Xinyan Yao1, Kexin Xu1, Nana Tao2,3

  • 1The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.

Virology Journal
|January 31, 2024
PubMed
Summary

Zinc finger protein 148 (ZNF148) inhibits hepatitis B virus (HBV) replication by reducing retinoid X receptor alpha (RXRα) expression. This discovery suggests ZNF148 as a potential new target for anti-HBV therapies.

Keywords:
HBVRXRαTranscription factorZNF148cccDNA

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