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Updated: Jul 4, 2025

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
Published on: August 13, 2017
Nuclear α-synuclein regulates transcription and affects neuronal differentiation
1Department of Neurology, Kansas University Medical Center, Kansas City, KS, USA.
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α-Synuclein is a member of the synuclein family well known for its involvement in Parkinson's disease and other synucleinopathies. Most studies investigate the mechanism of its involvement in pathology within the cell cytoplasm and extracellular space. However, despite a continuing interest in α-synuclein, two questions about this protein remain poorly understood. What is the normal physiological function of α-synuclein, and what does it do in the cell nucleus? A recent article by Takaaki Nakamura and colleagues contains at least a partial answer to both questions. The authors identified previously unknown α-synuclein-interacting proteins in the nucleus and showed that the protein complex containing α-synuclein modulates transcriptional profiles controlling the process of epigenetic alterations and neural differentiation.
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