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Related Concept Videos

Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Updated: Jul 4, 2025

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Open Science Practices in Psychiatric Genetics: A Primer.

Adrianna P Kępińska1,2,3,4,5, Jessica S Johnson1,6, Laura M Huckins1,2,3,4,7

  • 1Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York.

Biological Psychiatry Global Open Science
|February 1, 2024
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Summary

This primer offers guidance on open science practices in psychiatric genetics, addressing data, privacy, and conduct challenges. It promotes transparent, accessible research for better collaboration and reproducibility.

Keywords:
EquityMethodologyOpen accessOpen sciencePsychiatric geneticsReproducibility

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Area of Science:

  • Psychiatric Genetics
  • Open Science Practices
  • Research Ethics

Background:

  • Psychiatric genetics has adopted some open science practices, like replication in genome-wide association studies.
  • Limited guidelines exist for open science implementation specific to psychiatric genetics' unique challenges.
  • Challenges include data sharing, privacy concerns, and research conduct in this field.

Purpose of the Study:

  • To provide a comprehensive primer on open science practices tailored for psychiatric genetics research.
  • To address specific challenges related to data, privacy, and research conduct.
  • To promote transparency, reproducibility, and collaboration in the field.

Main Methods:

  • Discusses collaborative research topic selection with patients and nonacademic partners.
  • Details practices for replicable and reproducible study design, including preregistrations.
  • Covers open data principles, privacy considerations, and equitable authorship/citation.

Main Results:

  • Offers practical tips for creating informative figures and inclusive, precise reporting.
  • Provides guidance on engaging nonacademic collaborators and disseminating research through various channels.
  • Highlights the importance of accessible communication via preprints, blogs, social media, and lectures.

Conclusions:

  • Implementing thorough open science practices is crucial for advancing psychiatric genetics.
  • This primer equips researchers with actionable strategies for ethical and effective open science.
  • Enhanced open science in psychiatric genetics fosters greater transparency, collaboration, and public trust.