Related Experiment Video

Updated: Jul 4, 2025

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
09:58

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

20.8K

GH therapy in children with juvenile idiopathic arthritis: a four-decade review

Giulia Sassano1, Saverio La Bella1, Armando Di Ludovico1

  • 1Department of Pediatrics, University of Chieti-Pescara, Chieti, Italy.

Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology
|February 1, 2024
PubMed

Insights

Growth failure in juvenile idiopathic arthritis is linked to inflammation and steroids. Growth hormone therapy shows promise in improving growth and pubertal development in these patients.

Area of Science:

  • Pediatric Endocrinology
  • Rheumatology
  • Growth Disorders

Background:

  • Chronic inflammatory conditions like juvenile idiopathic arthritis (JIA) are linked to significant growth failure.
  • Inflammation and glucocorticoid treatments negatively impact the growth hormone axis, growth plate, and bone metabolism.
  • While biologics have improved JIA outcomes, they don't always restore normal growth.

Purpose of the Study:

  • To evaluate the impact of growth hormone (GH) treatment on growth and pubertal development in patients with JIA.
  • To review the literature over the past four decades concerning GH therapy in JIA.
  • To assess GH's efficacy when biologics alone are insufficient for growth recovery.

Main Methods:

  • A narrative review of scientific literature was conducted.
  • Studies published over the last 40 years were analyzed.
  • Focus was on research evaluating growth hormone treatment in JIA patients.

Main Results:

  • Several studies indicate that growth hormone treatment can improve height velocity and growth rate in JIA patients.
  • GH therapy may offer a viable option for patients unresponsive to other treatments.
  • Evidence suggests potential benefits for pubertal development alongside linear growth.

Conclusions:

  • Growth hormone treatment is a potential therapeutic strategy to address growth failure in juvenile idiopathic arthritis.
  • GH therapy may complement or be an alternative to existing treatments for optimizing growth outcomes in JIA.
  • Further research is warranted to fully elucidate the long-term effects and optimal use of GH in JIA.

Keywords:
growth failurejuvenile idiopathic arthritis (JIA)rhGHshort stature in JIA

More Related Videos

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.0K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

229

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.3K
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
120
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
174
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
166