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Updated: Jul 4, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Glp-1 Mimetics and Autophagy in Diabetic Milieu: State-of-the-Art
Habib Yaribeygi1, Mina Maleki2, Raul D Santos3
1Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Abstract:
The diabetic milieu is associated with cascades of pathophysiological pathways that culminate in diabetic complications and tissue injuries. Autophagy is an essential process mandatory for cell survival and tissue homeostasis by degrading damaged organelles and removing injured cells. However, it may turn into a pathological process in an aberrant mode in the diabetic and/or malignant milieu. Moreover, autophagy could serve as a promising therapeutic target for many complications related to tissue injury. Glp-1 mimetics are a class of newer antidiabetic agents that reduce blood glucose through several pathways. However, some evidence suggests that they can provide extra glycemic benefits by modulating autophagy, although there is no complete understanding of this mechanism and its underlying molecular pathways. Hence, in the current review, we aimed to provide new insights on the possible impact of Glp-1 mimetics on autophagy and consequent benefits as well as mediating pathways.
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