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Related Concept Videos

Teeth01:15

Teeth

424
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
424
Tooth Anatomy01:21

Tooth Anatomy

473
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
473
Assessment of the Mouth01:26

Assessment of the Mouth

214
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
214

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[The tooth: A marker of developmental abnormalities].

Muriel de La Dure-Molla1, Céline Gaucher2, Nicolas Dupré3

  • 1Centre de référence maladies rares orales et dentaires, O-Rares, hôpital Rothschild, AP-HP, Paris ; université Paris Cité, UFR d'odontologie, Inserm, UMR1163, bases moléculaires et physiopathologiques des ostéochondrodysplasies, institut imagine, Paris ; FHU DDS Paris-Net, filière TETECOU, European Reference Network CRANIO.

Medecine Sciences : M/S
|February 1, 2024
PubMed
Summary

Tooth formation involves complex epithelial-mesenchymal interactions, crucial for dental development. Anomalies can indicate underlying systemic diseases affecting mineral metabolism, skin, or nervous system, highlighting the need for multidisciplinary care.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Oral Biology

Context:

  • Tooth formation is a complex process driven by epithelial-mesenchymal interactions.
  • These interactions are guided by signaling pathways and transcription factors, including PITX2, BMP, FGF, SHH, and WNT.
  • Alterations in these processes can lead to various tooth anomalies.

Purpose:

  • To elucidate the intricate mechanisms of tooth formation.
  • To highlight the connection between tooth anomalies and broader systemic health conditions.
  • To emphasize the role of genetic and molecular factors in odontogenesis.

Summary:

  • Tooth development initiates early in intrauterine life, guided by specific molecular signals like PITX2.
  • Subsequent stages involve intricate ecto-mesenchymal interactions regulating cell behavior and differentiation.
  • These interactions are essential for determining tooth number, shape, size, and the formation of dental mineralized tissues.

Impact:

  • Tooth anomalies can serve as clinical indicators for subclinical diseases affecting the kidney, bone, mineral metabolism, skin, or nervous system.
  • Understanding these developmental pathways is crucial for comprehensive patient phenotyping and multidisciplinary care.
  • Identifying disruptions in the genetic circuitry of odontogenesis can aid in diagnosing and managing associated genetic disorders.