Related Experiment Video
Updated: Jul 4, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.1K
Paradigm Shifting Research: Key Studies in Urologic Oncology
1Department of Urology, The Ohio State University, Columbus, OH, USA.
Annals of Surgical Oncology
|February 1, 2024
Summary
Advances in urologic cancer treatment offer improved outcomes. Key trials show benefits for active monitoring in prostate cancer, lymph node dissection for testicular cancer, immunotherapy for bladder cancer, and radiotherapy for kidney cancer.
Area of Science:
- Urology
- Oncology
- Medical Research
Background:
- Genitourinary malignancies, including prostate, renal, and bladder cancers, significantly impact public health.
- Less common urinary tract cancers present unique challenges regarding functional deficits.
Purpose of the Study:
- To review pivotal clinical trials from 2022 impacting urologic oncology practice.
- To highlight evidence-based advancements in treating genitourinary cancers.
Main Methods:
- Literature review focusing on the four most influential clinical practice articles from 2022.
- Analysis of data from prospective randomized clinical trials and collaborative groups.
Main Results:
- The PROTECT trial shows positive 15-year outcomes for active monitoring of localized prostate cancer.
- SEMS trial supports retroperitoneal lymph node dissection for testicular seminoma.
- CheckMate 274 trial indicates benefit of adjuvant immunotherapy for muscle-invasive bladder cancer.
- IROCK consortium data reinforce stereotactic radiotherapy for localized renal cell carcinoma.
Conclusions:
- Surgical, medical, and radiation oncology treatments for urologic cancers have advanced significantly.
- Prospective trials and collaborative research drive improvements in patient care for urologic malignancies.
Related Concept Videos
02:43Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:21Cancer Survival Analysis
348
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
348