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Associations of Temporal Cardiometabolic Patterns and Incident SARS-CoV-2 Infection Among U.S. Blood Donors With

Elaine A Yu1,2, Mars Stone1,2, Marjorie D Bravo3

  • 1Vitalant Research Institute, San Francisco, California.

AJPM Focus
|February 2, 2024
PubMed

Insights

Maintaining good cardiometabolic health, especially controlled blood pressure, is crucial for reducing SARS-CoV-2 infection risk post-vaccination. Intermittent hypertension and elevated cholesterol in men were linked to increased infection rates.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiometabolic diseases increase COVID-19 severity.
  • The impact of cardiometabolic health on SARS-CoV-2 infection risk after vaccination is not well understood.

Purpose of the Study:

  • To examine the relationship between blood pressure and total cholesterol patterns and SARS-CoV-2 infections in vaccinated individuals.

Main Methods:

  • A prospective cohort study of 13,930 blood donors (2020-2021).
  • Assessed SARS-CoV-2 nucleocapsid antibody seropositivity and categorized blood pressure/cholesterol patterns (persistently, intermittently, or not elevated).

Main Results:

  • 221 (1.6%) incident SARS-CoV-2 infections occurred in vaccinated participants.
  • Intermittent hypertension increased infection risk (aIRR=2.07).
  • In men, intermittently elevated cholesterol (aIRR=1.90) and higher BMI were associated with increased infection risk; associations were not significant in women.

Conclusions:

  • Good cardiometabolic health, particularly controlled blood pressure, is associated with a lower risk of SARS-CoV-2 infection after vaccination.
  • Findings highlight the importance of managing blood pressure and cholesterol for post-vaccination protection against SARS-CoV-2.
Abstract

Keywords:
BMISARS-CoV-2blood pressureinfectionvaccine

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