Related Experiment Video
Updated: Jul 4, 2025
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
12.9K
Antibiotics in anesthesia and critical care
Antoine Premachandra1, Pierre Moine1,2,3
1Department of Intensive Care, Hôpital Raymond Poincaré, Groupe Hospitalo-Universitaire GHU AP-HP, University Versailles Saint Quentin-University Paris-Saclay, Garches, France.
Annals of Translational Medicine
|February 2, 2024
Summary
Sepsis management requires careful antimicrobial use to reduce mortality and prevent resistance. Optimizing antibiotic therapy, considering factors like surgical site infections and microbiota impact, is crucial for patient outcomes.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pharmacology
Background:
- Sepsis, a global health crisis, causes millions of deaths annually.
- Antimicrobials are vital for sepsis treatment but pose risks like adverse effects and resistance.
- Inappropriate antibiotic use, whether inadequate or overly broad, increases mortality and selects for resistant bacteria.
Purpose of the Study:
- To review factors influencing surgical site infections and perioperative antibiotic prophylaxis.
- To summarize advancements in optimizing antibiotic therapy in intensive care units.
- To discuss the role of microbiota and antimicrobial impact.
Main Methods:
- Narrative review of current literature and expert recommendations.
- Discussion of pharmacokinetic/pharmacodynamic (PK/PD) principles.
- Analysis of factors affecting surgical site infections and perioperative antibiotic prophylaxis.
Main Results:
- Surgical site infection risk factors and perioperative antibiotic prophylaxis considerations are detailed.
- Recent strategies for optimizing intensive care unit antibiotic therapy are presented.
- The significant impact of antimicrobials on the microbiota and the emergence of resistance is highlighted.
Conclusions:
- Optimizing antibiotic therapy in sepsis requires a nuanced approach, balancing efficacy with the risks of resistance.
- Understanding PK/PD principles is essential for managing complex patients and minimizing multidrug-resistant organism emergence.
- Integrating knowledge of surgical site infections, intensive care unit therapies, and microbiota impact is key to improving sepsis outcomes.
Keywords:
Antibioticsmicrobiotapharmacokinetic/pharmacodynamic (PK/PD)septic shocksurgical prophylaxisMore Related Videos
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