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Nail changes caused by systemic drugs or ingestants.

C R Daniel, R K Scher

    Dermatologic Clinics
    |July 1, 1985
    PubMed
    Summary

    Systemic drugs and ingestants can alter nail appearance and growth. Common nail changes include altered growth rates and pigmentation, while less frequent effects involve shedding or deformity.

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    Area of Science:

    • Dermatology
    • Toxicology
    • Pharmacology

    Background:

    • Systemic medications and ingested substances can manifest observable changes in the nails.
    • Nail alterations present a spectrum from subtle, asymptomatic variations to significant structural damage.

    Purpose of the Study:

    • To review and categorize nail changes induced by various systemic drugs and ingestants.
    • To highlight the most prevalent nail abnormalities associated with specific drug classes.

    Main Methods:

    • Literature review of documented nail pathologies linked to systemic agents.
    • Categorization of nail changes based on causative agents, including antibiotics, chemotherapy, antimalarials, poisons, and other miscellaneous drugs.

    Main Results:

    • Antibiotics, cancer chemotherapeutics, poisons, antimalarials, and other drugs can induce diverse nail changes.
    • Asymptomatic alterations in nail growth rate and pigmentation represent the most frequent manifestations.

    Conclusions:

    • Clinicians should be aware of the potential for systemic drugs and ingestants to cause nail abnormalities.
    • Recognizing drug-induced nail changes is crucial for diagnosis and patient management.

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