Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Odd Lilleng Gammelgaard1, Per Guldberg1,2, Morten F Gjerstorff1,3,4

  • 1Institut for Kræft- og Inflammationsforskning, Institut for Molekylær Medicin, Syddansk Universitet.

Ugeskrift for Laeger
|February 2, 2024
PubMed
Summary

Aging significantly increases cancer risk due to genetic and microenvironmental changes. Tumors in older adults show distinct genetic profiles and immune dysregulation, impacting treatment effectiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stable global repertoire architecture masks short-term clonal remodeling in intratumoral TCR repertoires.

Frontiers in immunology·2026
Same author

Adoptive cell transfer therapy with ex vivo primed peripheral lymphocytes in combination with chemotherapy in locally advanced or metastatic triple-negative breast cancer: the ImmunoBreast phase Ib clinical trial.

Journal for immunotherapy of cancer·2025
Same author

[Vaccination of individuals undergoing immunosuppressive therapy].

Ugeskrift for laeger·2025
Same author

Systematic design of DMBT1-derived peptides correlating physicochemical properties and sequence motifs with siRNA delivery and efficacy in cancer therapy.

EBioMedicine·2025
Same author

Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition.

Journal of experimental & clinical cancer research : CR·2025
Same author

Correction: Mansoori et al. HMGA2 Supports Cancer Hallmarks in Triple-Negative Breast Cancer. <i>Cancers</i> 2021, <i>13</i>, 5197.

Cancers·2024

Area of Science:

  • Oncology
  • Gerontology
  • Immunology

Background:

  • Cancer incidence rises exponentially with age.
  • Age-related genetic, epigenetic, and microenvironmental factors influence cancer development.
  • The aging immune system plays a critical role in cancer progression and treatment resistance.

Conclusions:

  • Aging profoundly influences cancer development and progression through complex molecular and cellular mechanisms.
  • Distinct tumor characteristics in older adults necessitate tailored therapeutic strategies.
  • Further research into age-related cancer biology is crucial for improving outcomes in the elderly population.

Related Experiment Videos