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Updated: Jul 4, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
Published on: August 14, 2018
Bridge: A New Algorithm for Rooting Orthologous Genes in Large-Scale Evolutionary Analyses
Leonardo R S Campos1, Sheyla Trefflich2, Diego A A Morais1
1Bioinformatics Multidisciplinary Environment-BioME, IMD, Federal University of Rio Grande do Norte, Natal, Brazil.
Abstract:
Orthology information has been used for searching patterns in high-dimensional data, allowing transferring functional information between species. The key concept behind this strategy is that orthologous genes share ancestry to some extent. While reconstructing the history of a single gene is feasible with the existing computational resources, the reconstruction of entire biological systems remains challenging. In this study, we present Bridge, a new algorithm designed to infer the evolutionary root of orthologous genes in large-scale evolutionary analyses. The Bridge algorithm infers the evolutionary root of a given gene based on the distribution of its orthologs in a species tree. The Bridge algorithm is implemented in R and can be used either to assess genetic changes across the evolutionary history of orthologous groups or to infer the onset of specific traits in a biological system.
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