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Blood Test-Based Age Acceleration Is Inversely Associated with High-Volume Sports Activity.

Vencel Juhász¹, Anna Ország², Dorottya Balla¹

¹Heart and Vascular Centre, Semmelweis University, Budapest, HUNGARY.

Medicine and Science in Sports and Exercise

|February 2, 2024

Summary

This summary is machine-generated.

High-volume sports activity may slow biological aging, as indicated by blood test-based aging clocks. Athletes showed lower age acceleration compared to controls, suggesting a link between intense exercise and slower aging processes.

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Area of Science:

Biogerontology
Sports Medicine
Biomarker Discovery

Background:

Biological aging can be assessed using epigenetic clocks and other biomarkers.
High-volume sports activity may influence physiological markers of aging.
Understanding the relationship between athletic performance and aging is crucial for health and longevity.

Purpose of the Study:

To develop blood test-based aging clocks.
To investigate the association between high-volume sports activity and biological aging.
To explore the utility of routine blood tests in assessing aging in athletes.

Main Methods:

Utilized blood tests and body metrics from 421 Hungarian athletes and 283 age-matched controls.
Trained two age prediction models (aging clocks) using National Health and Nutrition Examination Survey (NHANES) data.
Compared age acceleration between athletes and controls, and analyzed associations with Body Mass Index (BMI), body fat percentage, and skeletal muscle mass.

Main Results:

Athletes exhibited significantly lower age acceleration (-1.7 yr) compared to age-matched controls (1.4 yr).
No association was found between BMI and age acceleration in athletes; however, body fat percentage was positively associated, and skeletal muscle mass negatively associated.
Key blood test features for age prediction included serum ferritin, mean cell volume, blood urea nitrogen, and albumin.

Conclusions:

Blood test-based aging clocks demonstrate that high-volume sports activity is linked to slowed biological aging.
Routine blood tests offer a promising avenue for assessing aging in athletes.
These findings highlight the potential of sports participation in modulating the aging process.