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Updated: Jul 4, 2025

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
Published on: July 16, 2018
Sham surgery for the trialing of cell-based therapies to the CNS may not be necessary
Viviane Tabar1, Roger A Barker2
1Department of Neurosurgery, Cancer Biology and Genetics program, Sloan Kettering Institute, New York, NY 10075, USA.
Abstract:
Sham surgery is often required for cell therapies adopting a randomized placebo-controlled double-blinded trial design. Using the case of dopamine neuron therapy for Parkinson's disease, we argue that alternative trial designs should be considered instead, for several reasons relating to ethics, patient burden, ease of unblinding, and cost.
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