Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

5.2K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.

NMR in biomedicine·2026
Same author

Narrative coherence shapes functional connectivity in default mode and frontoparietal networks.

Neuroimage. Reports·2026
Same author

Myelin damage in radiologically isolated syndrome is associated with decreased processing speed.

Multiple sclerosis journal - experimental, translational and clinical·2026
Same author

Correction: Data-driven disease subgrouping in ALS: a multicenter cerebral functional connectivity study.

Journal of neurology·2026
Same author

Patient reported outcomes in NMOSD reflect a high disease burden and do not correlate with the EDSS.

Multiple sclerosis and related disorders·2026
Same author

DeepRelaxo: Fast Mono-Exponential Magnitude Brain R2* Mapping With Reduced Echoes Using Self-Supervised Deep Learning.

Magnetic resonance in medicine·2026

Related Experiment Video

Updated: Jul 4, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.0K

MR Susceptibility Separation for Quantifying Lesion Paramagnetic and Diamagnetic Evolution in Relapsing-Remitting

Ziyan Zhu1, Nashwan Naji1,2, Javad Hamidi Esfahani1

  • 1Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.

Journal of Magnetic Resonance Imaging : JMRI
|February 3, 2024
PubMed
Summary

Susceptibility separation in multiple sclerosis (MS) lesions quantifies paramagnetic and diamagnetic changes over time. This advanced MRI technique offers deeper insights into MS lesion evolution than conventional methods alone.

Keywords:
lesion evolutionmagnetic susceptibility separationmultiple sclerosisquantitative susceptibility mapping

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.1K

Related Experiment Videos

Last Updated: Jul 4, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.0K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.1K

Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Multiple sclerosis (MS) lesion evolution involves complex changes in myelin and iron content.
  • Conventional quantitative susceptibility mapping (QSM) provides net magnetic susceptibility but not discrete paramagnetic and diamagnetic components.
  • Distinguishing these components is crucial for understanding MS lesion dynamics.

Purpose of the Study:

  • To apply susceptibility separation (χ separation) for tracking MS lesion evolution.
  • To compare susceptibility separation with established MRI techniques like R2*, R2', and QSM.
  • To investigate the paramagnetic and diamagnetic contributions to MS lesion changes.

Main Methods:

  • Longitudinal, prospective study of 20 relapsing-remitting MS patients.
  • Utilized 3D multi-echo gradient echo and 2D dual echo fast spin echo sequences at 3T.
  • Applied susceptibility separation to quantify voxel-wise paramagnetic and diamagnetic content.

Main Results:

  • Analyzed 183 lesions over a mean interval of 14.4 months.
  • Susceptibility separation revealed significant annual changes in paramagnetic and diamagnetic components.
  • Correlations confirmed associations between susceptibility-sensitive MRI indices and χ separation outcomes.

Conclusions:

  • Susceptibility separation effectively distinguishes and quantifies paramagnetic and diamagnetic evolution in MS lesions.
  • This method offers potentially greater insight into MS lesion dynamics compared to R2* and QSM alone.
  • Further research can leverage susceptibility separation for improved understanding and monitoring of MS.