Related Experiment Video
Updated: Jul 4, 2025
07:51
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
10.6K
Contingency management plus acceptance and commitment therapy for initial cocaine abstinence: Results of a sequential
Joy M Schmitz1, Angela L Stotts2, Anka A Vujanovic3
1Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, United States.
Drug and Alcohol Dependence
|February 3, 2024
Summary
Acceptance and Commitment Therapy (ACT) combined with contingency management (CM) improved cocaine abstinence initiation. Modafinil did not enhance outcomes for non-responders, who were less likely to maintain abstinence.
Area of Science:
- Psychiatry
- Clinical Psychology
- Addiction Medicine
Background:
- Cocaine use disorder (CUD) treatment requires optimizing abstinence outcomes.
- Adaptive interventions and SMART designs can personalize treatment phases.
- Contingency management (CM) is a key component in CUD treatment.
Purpose of the Study:
- To test an adaptive intervention for optimizing abstinence in CUD.
- To assess if Acceptance and Commitment Therapy (ACT) added to CM improves Phase 1 response.
- To evaluate modafinil (MOD) vs. placebo (PLA) augmentation for Phase 1 non-responders.
Main Methods:
- A Sequential Multiple Assignment Randomized Trial (SMART) design was used.
- Phase 1: 118 participants randomized to ACT+CM or Drug Counseling (DC+CM).
- Phase 2: Non-responders re-randomized to MOD or PLA; responders continued treatment.
Main Results:
- Phase 1 response rate was higher with ACT+CM (24.5%) vs. DC+CM (17.5%).
- Phase 1 responders maintained higher abstinence rates than non-responders.
- Modafinil augmentation showed no significant effect in Phase 2.
Conclusions:
- Adding ACT to CM enhances cocaine abstinence initiation.
- Initial treatment responders demonstrate better sustained abstinence.
- Modafinil is not an effective pharmacotherapy for augmenting treatment in CUD non-responders.
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