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Updated: Jul 4, 2025

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
Published on: September 2, 2019
Novel insights into the post-translational modifications of Ydj1/DNAJA1 co-chaperones
Megan M Mitchem1, Courtney Shrader1, Elizabeth Abedi1
1Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Abstract:
The activity of the Hsp70 molecular chaperone is regulated by a suite of helper co-chaperones that include J-proteins. Studies on J-proteins have historically focused on their expression, localization, and activation of Hsp70. There is growing evidence that the post-translational modifications (PTMs) of chaperones (the chaperone code) fine-tune chaperone function. This mini-review summarizes the current understanding of the role and regulation of PTMs on the major J-proteins Ydj1 and DNAJA1. Understanding these PTMs may provide novel therapeutic avenues for targeting chaperone activity in cancer and neurodegenerative diseases.
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