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Towards single-cell bioprinting: micropatterning tools for organ-on-chip development
Cécile Bosmans1, Núria Ginés Rodriguez2, Marcel Karperien1
1Department of Developmental BioEngineering, University of Twente, Enschede, The Netherlands.
Trends in Biotechnology
|February 3, 2024
Summary
Organs-on-chips (OoCs) can better mimic human physiology by incorporating microarchitectural features. Advanced micropatterning technologies are key to developing next-generation OoCs for pharmaceutical research.
Area of Science:
- Biomedical Engineering
- Tissue Engineering
- Drug Discovery
Background:
- Organs-on-chips (OoCs) are advanced in vitro models for pharmaceutical research.
- Current OoCs struggle to replicate native human tissue physiology.
- There is a need for improved structural complexity in OoC models.
Purpose of the Study:
- To highlight the importance of microarchitectural and microstructural features in OoCs.
- To discuss methods for incorporating these features into OoC designs.
- To explore the potential of advanced technologies for next-generation OoCs.
Main Methods:
- Review of current literature on OoC development.
- Analysis of microarchitectural and microstructural integration strategies.
- Discussion of micropatterning technologies for complex tissue engineering.
Main Results:
- OoCs require enhanced microarchitectural and microstructural complexity to better mimic human physiology.
- Integrating features down to the single-cell level is crucial.
- Advanced micropatterning techniques enable the creation of highly organized tissues-on-chip.
Conclusions:
- Incorporating microarchitectural and microstructural features is essential for advancing OoC technology.
- Next-generation OoCs will achieve greater human-intrinsic complexity.
- These innovations promise significant progress in pharmaceutical research and drug development.
