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Intelligent Drug Delivery: Pioneering Stimuli-Responsive Systems to Revolutionize Disease Management- An In-depth
Badarinadh Kallepalli1, Unnati Garg1, Neha Jain1
1Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India.
Current Drug Delivery
|February 4, 2024
Summary
Stimuli-responsive drug delivery systems (SRDDS) offer precise, targeted therapeutic delivery by responding to internal or external cues. This review explores their principles, applications in diseases like cancer, and future potential.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmacology
Background:
- Stimuli-responsive drug delivery systems (SRDDS) are gaining interest for advanced therapeutics.
- SRDDS offer advantages over conventional systems, including controlled release and targeted delivery.
- Advances in materials science and biotechnology drive the development of diverse SRDDS.
Purpose of the Study:
- To provide an in-depth review of SRDDS principles, mechanisms, and applications.
- To explore SRDDS potential in treating various pathologies like cancer, arthritis, Alzheimer's, and atherosclerosis.
- To discuss recent patents, market trends, and clinical trial progress for SRDDS.
Main Methods:
- Literature review of stimuli-responsive drug delivery systems.
- Exploration of different responsive mechanisms (pH, temperature, light, redox).
- Analysis of SRDDS applications in diverse disease models and tissue engineering.
Main Results:
- SRDDS exploit specific cues for controlled drug release, enhancing therapeutic efficacy.
- Applications span oncology, rheumatology, neurology, cardiovascular diseases, and regenerative medicine.
- Recent patents and ongoing clinical trials indicate significant research and development momentum.
Conclusions:
- SRDDS represent a transformative approach to personalized and precise medicine.
- These systems hold immense promise for improving treatment outcomes across multiple diseases.
- Continued research and clinical translation are expected to expand SRDDS applications.
Keywords:
Chemical-responsive drug delivery systemsIntelligent PolymersIntelligent biomaterialsPhysicalresponsive drug delivery systemsSRDDS market overviewStimuli-responsive drug delivery systems (SRDDS)endogenous/exogenous stimuli-responsive DDS.More Related Videos
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