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Microcirculation in the elderly.

G Tassi, G Maggi, P de Nicola

    International Angiology : a Journal of the International Union of Angiology
    |July 1, 1985
    PubMed
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    Microcirculation in the elderly shows typical changes in vascular diseases. Vasoactive drugs significantly improve conjunctival vessel appearance and blood flow, aiding in managing these conditions.

    Area of Science:

    • Gerontology
    • Vascular Biology
    • Ophthalmology

    Background:

    • Microcirculation in the elderly exhibits characteristic changes.
    • Capillaroscopic findings in the bulbar conjunctiva and nailbed are crucial for assessing vascular health.

    Purpose of the Study:

    • To analyze microcirculatory alterations in the elderly.
    • To evaluate the impact of vasoactive drugs on conjunctival microvasculature.

    Main Methods:

    • Capillaroscopy of bulbar conjunctiva and nailbed.
    • Assessment of semeiologic criteria: diameter/shape, capillary network, red cell aggregation.
    • Observation during treatment with vasoactive drugs (nicotinic acid derivatives, buflomedil, CPD-choline).

    Main Results:

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    • Typical capillaroscopic alterations observed in elderly vascular diseases like arteriosclerosis, hypertension, and diabetic microangiopathy.
    • Vasoactive drug treatment led to vessel dilation, collateral formation, improved blood flow homogeneity, and reduced red cell aggregation.
    • Enhanced visualization of the capillary network was noted.

    Conclusions:

    • Microcirculatory assessment in the elderly is vital for diagnosing vascular conditions.
    • Vasoactive drugs demonstrate significant efficacy in ameliorating microcirculatory impairments in the elderly.
    • Conjunctival capillaroscopy serves as a valuable tool for monitoring treatment response.