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Perphenazine in Treatment-Resistant Schizophrenia
Michael R Hower1, Surya Kumar Karlapati2, Anil K Bachu1,3
1Psychiatry and Behavioral Sciences, Baptist Health - University of Arkansas for Medical Sciences, Little Rock, USA.
Cureus
|February 5, 2024
Summary
This case report details a 38-year-old male with schizophrenia experiencing acute psychosis resistant to multiple antipsychotics. Perphenazine treatment led to significant improvement, highlighting its potential in treatment-resistant cases.
Area of Science:
- Psychiatry
- Neuroscience
- Pharmacology
Background:
- Schizophrenia treatment typically involves antipsychotics, but medication choice varies due to symptoms, prior response, and side effects.
- Treatment resistance is a significant challenge in managing schizophrenia, necessitating exploration of alternative therapeutic strategies.
Observation:
- A 38-year-old male patient with schizophrenia presented with acute psychosis refractory to multiple antipsychotic medications.
- The patient's comprehensive history, including psychiatric, medical, social, and previous medication trials, was reviewed.
Findings:
- The initiation of perphenazine was explored as a treatment option for this refractory case.
- The patient demonstrated notable clinical improvement following the introduction of perphenazine.
Implications:
- This case suggests perphenazine may be an effective option for schizophrenia patients with treatment-resistant psychosis.
- Further research into perphenazine's efficacy and limitations in managing refractory schizophrenia is warranted.
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