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Related Concept Videos

Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Drug Administration and Therapy Phases: Overview01:26

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
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Pharmacodynamics: Overview and Principles01:21

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Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Pharmacokinetics: Overview01:10

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Pharmacokinetics is a scientific discipline that focuses on the journey of a drug within the body, encompassing four key stages: absorption, distribution, metabolism, and elimination. The first stage, absorption, involves the drug's transfer into the bloodstream. Several factors dictate the extent and speed of this process. For example, the liver often metabolizes oral drugs before they reach systemic circulation, leading to only partial absorption. In contrast, intravenous (IV)...
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Related Experiment Video

Updated: Jul 4, 2025

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
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Using PharmaPy with Jupyter Notebook to teach digital design in pharmaceutical manufacturing.

Daniel J Laky1,2, Daniel Casas-Orozco1, Mesfin Abdi3

  • 1Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana, USA.

Computer Applications in Engineering Education
|February 5, 2024
PubMed
Summary

This study introduces PharmaPy, an open-source tool for pharmaceutical manufacturing simulation. Students found PharmaPy approachable via Jupyter Notebook, enhancing their understanding of active pharmaceutical ingredient process design.

Keywords:
Jupyter NotebookPythondigital designengineering educationpharmaceutical manufacturingsmart manufacturing

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Area of Science:

  • Chemical Engineering
  • Pharmaceutical Sciences
  • Computational Modeling

Background:

  • Digital tools are increasingly vital in pharmaceutical manufacturing, driven by Industry 4.0 standards.
  • Engineers require proficiency in digital analysis techniques like modeling, simulation, and data processing.
  • Traditional simulation tools may not fully address the evolving needs of pharmaceutical process development.

Purpose of the Study:

  • To evaluate the effectiveness of PharmaPy, a new open-source pharmaceutical manufacturing simulator, in an academic setting.
  • To assess student learning outcomes when using PharmaPy within a chemical engineering course.
  • To determine the suitability of PharmaPy for teaching active pharmaceutical ingredient (API) process design and development.

Main Methods:

  • A chemical engineering course on digital tools was adapted to incorporate PharmaPy.
  • Jupyter Notebook was used as the interactive environment for teaching PharmaPy.
  • Students utilized PharmaPy's model library to simulate unit operations and multiunit pharmaceutical processes.
  • Post-course surveys were administered to gather student feedback on PharmaPy's usability and effectiveness.

Main Results:

  • Students reported that learning Python and PharmaPy through Jupyter Notebook was accessible, regardless of prior coding experience.
  • PharmaPy was found to enhance students' comprehension of pharmaceutical manufacturing principles.
  • The simulation of individual unit operations and complex multiunit processes was successfully demonstrated using PharmaPy.
  • Initial survey results indicated a positive reception of PharmaPy as a learning tool.

Conclusions:

  • PharmaPy, when integrated with Jupyter Notebook, offers an approachable platform for learning pharmaceutical process simulation.
  • The tool effectively supports the learning objectives related to active pharmaceutical ingredient process design and development.
  • PharmaPy shows promise as a valuable resource for training future pharmaceutical engineers in digital manufacturing techniques.
  • Further integration of PharmaPy into curricula can bolster digital literacy in the pharmaceutical industry.