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Related Concept Videos

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T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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The JAK-STAT Signaling Pathway01:20

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Related Experiment Video

Updated: Jul 4, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Interleukins and Psoriasis.

Qi Zhu1,2,3, Linna Zhao1,2,4, Haining Ding3

  • 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Journal of Cutaneous Medicine and Surgery
|February 5, 2024
PubMed
Summary
This summary is machine-generated.

This review explores the role of interleukins (ILs) in psoriasis, a chronic inflammatory skin disease. It summarizes IL contributions to psoriasis pathogenesis and discusses biologic therapies targeting ILs for improved treatment outcomes.

Keywords:
biologic drugscytokinesinflammationinterleukinspsoriasis

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Area of Science:

  • Immunology
  • Dermatology
  • Pharmacology

Background:

  • Psoriasis is a prevalent immune-mediated chronic inflammatory skin disease affecting 2-3% of the global population.
  • Immune cells and cytokines, particularly interleukins (ILs), are critical in psoriasis pathophysiology, driving keratinocyte proliferation and inflammation.

Purpose of the Study:

  • To review the current understanding of Interleukin (IL) involvement in psoriasis.
  • To detail the specific roles of individual ILs in the pathogenesis and progression of psoriasis.
  • To examine the therapeutic potential and clinical applications of IL-targeting biologics for psoriasis treatment.

Main Methods:

  • Literature review of current research on interleukins and psoriasis.
  • Analysis of the pathogenetic mechanisms involving specific ILs in psoriasis.
  • Evaluation of clinical and experimental data on biologic therapies targeting ILs.

Main Results:

  • Interleukins are significantly implicated in the development and advancement of psoriasis.
  • Specific ILs play distinct roles in the inflammatory processes and skin cell overgrowth characteristic of psoriasis.
  • Biologic therapies targeting ILs demonstrate promising therapeutic effects and application prospects in clinical settings.

Conclusions:

  • Interleukins are key drivers in psoriasis pathogenesis.
  • Targeting specific ILs with biologics offers a promising therapeutic strategy for managing psoriasis.
  • Further research into ILs and their targeted therapies is crucial for advancing psoriasis treatment.