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Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Peripheral Nervous System: Ganglia and Nerves01:24

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
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Updated: Jul 4, 2025

Structured Motor Rehabilitation After Selective Nerve Transfers
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[Nerve Transfers in Peripheral Nerve Lesions].

Julia Janine Glaser1, Martin Aman1, Arne Hendrik Böcker1

  • 1Abteilung Handchirurgie, Periphere Nervenchirurgie, Rehabilitation, BG Klinik Ludwigshafen, Germany.

Handchirurgie, Mikrochirurgie, Plastische Chirurgie : Organ Der Deutschsprachigen Arbeitsgemeinschaft Fur Handchirurgie : Organ Der Deutschsprachigen Arbeitsgemeinschaft Fur Mikrochirurgie Der Peripheren Nerven Und Gefasse : Organ Der V
|February 5, 2024
PubMed
Summary

Early nerve transfers for upper extremity injuries improve motor and sensory function by shortening reinnervation distances. This surgical approach facilitates quicker recovery and better outcomes for patients with peripheral nerve damage.

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Area of Science:

  • Orthopedic Surgery
  • Neurosurgery
  • Regenerative Medicine

Context:

  • Peripheral nerve injuries in the upper extremities cause significant motor and sensory deficits.
  • These limitations lead to profound personal, professional, and socioeconomic challenges for affected individuals.

Purpose:

  • To evaluate the efficacy of nerve transfers in restoring function after upper extremity nerve injuries.
  • To determine the optimal timing for nerve transfer surgery considering reinnervation distance and donor site morbidity.

Summary:

  • Nerve transfers enable earlier and more reliable reinnervation of damaged nerves in the upper limb.
  • This surgical technique promotes improved axonal growth towards target organs, enhancing both motor and sensory recovery.
  • Individualized surgical planning is crucial, factoring in the length of the nerve gap and potential complications at the donor nerve site.

Impact:

  • Facilitates earlier restoration of mobility and sensation in patients with upper extremity nerve injuries.
  • Potentially reduces the long-term physical, psychological, and socioeconomic burden on patients.
  • Offers a promising strategy for improving surgical outcomes in peripheral nerve reconstruction.