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Association between the triglyceride glucose index and heart failure: NHANES 2007-2018

Fudan Zhang1, Xu Hou2

  • 1Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Frontiers in Endocrinology
|February 6, 2024
PubMed

Insights

The triglyceride glucose (TyG) index is linked to a higher risk of heart failure (HF) in individuals with cardiovascular disease. This index may serve as a key predictor and potential therapeutic target for HF.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Public Health

Background:

  • Heart failure (HF) poses a significant global health burden.
  • Understanding novel risk predictors for HF is crucial for early intervention.
  • The triglyceride glucose (TyG) index, a marker of insulin resistance, has emerged as a potential factor in cardiovascular health.

Purpose of the Study:

  • To investigate the association between the triglyceride glucose (TyG) index and the risk of heart failure (HF).
  • To explore the TyG index as a potential predictor in patients with existing cardiovascular and cerebrovascular diseases.

Main Methods:

  • Analysis of data from the National Health and Nutrition Examination Survey (NHANES) (2007-2018).
  • Inclusion of 13,825 participants, with 435 diagnosed with HF.
  • Calculation of the TyG index using ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2].
  • Application of multivariate logistic regression and restricted cubic spline (RCS) analysis to assess the association and dose-response relationship.

Main Results:

  • Individuals with HF exhibited significantly higher TyG index levels compared to those without HF (8.91 ± 0.74 vs. 8.57 ± 0.66, p < 0.001).
  • A higher TyG index was associated with an increased risk of HF, with an adjusted odds ratio of 1.057 (Model 4).
  • A linear dose-response relationship was observed between the TyG index and HF risk.
  • The TyG index demonstrated predictive value for HF with an ROC curve area of 0.602 (p < 0.001).

Conclusions:

  • The triglyceride glucose (TyG) index is positively associated with an increased risk of heart failure.
  • The TyG index may serve as a valuable therapeutic target for managing and predicting HF.
  • This study highlights the clinical utility of the TyG index in cardiovascular risk assessment.
Abstract

Keywords:
NHANEScardiovascular diseaseheart failurenonlinear associationstriglyceride glucose index

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