Related Experiment Video
Updated: Jul 4, 2025

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
Published on: January 31, 2014
Strategies to Account for Design Misspecifications in Randomized Controlled Trials
Amy S Ruppert1, Sumithra J Mandrekar2
1Division of Hematology, The Ohio State University, Columbus, OH.
Abstract:
Mortality rates of infants (younger than 1 year of age) and neonates (younger than 1 month of age) remain unacceptably high in some geographic regions.1,2 After the first week of life, infection is a significant cause of neonatal and postneonatal mortality.3,4 Biannual mass azithromycin administration has been shown to reduce all-cause childhood mortality by as much as 25% among infants 1 to 5 months of age in Niger.5.
Related Concept Videos
Strategies for Assessing and Addressing Confounding
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Randomized Experiments
Simple randomization
Simple...
Blinding
Group Design
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Study Design in Statistics
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...

