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Pediatric Patch Testing at Mayo Clinic Between 2016 and 2020

Katherine L Wang1, Erin M Rainosek2, Yul W Yang3

  • 1From the Mayo Clinic Alix School of Medicine, Jacksonville, Florida, USA.

Dermatitis : Contact, Atopic, Occupational, Drug
|February 6, 2024
PubMed

Insights

Allergic contact dermatitis (ACD) in children is common. Patch testing identified hydroperoxides of linalool, limonene, methylisothiazolinone, nickel, and cobalt as frequent allergens, suggesting updates to pediatric testing series.

Area of Science:

  • Dermatology
  • Pediatric Allergy
  • Contact Dermatitis

Background:

  • Allergic contact dermatitis (ACD) is a prevalent skin condition in children.
  • Patch testing is crucial for identifying specific allergens causing ACD in pediatric patients.

Purpose of the Study:

  • To update the understanding of common contact allergens in children.
  • To analyze patch testing data from a pediatric population between 2016 and 2020.

Main Methods:

  • Retrospective analysis of patch test data from 192 children (aged 1-18) at Mayo Clinic (2016-2020).
  • Comparison of institutional reaction rates with data from the Pediatric Contact Dermatitis Registry (PCDR).

Main Results:

  • The top five allergens with the highest positive reaction rates were hydroperoxides of linalool, hydroperoxides of limonene, methylisothiazolinone, nickel, and cobalt.
  • Seven of the top 38 allergens are not in the current Mayo Clinic Pediatric Patch Test Series.
  • Eleven allergens are not included in the Pediatric Baseline Series.

Conclusions:

  • Patch testing remains a valuable diagnostic tool for pediatric ACD.
  • The emergence of new products and exposures necessitates expanding current pediatric patch testing series to improve diagnostic accuracy.

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