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Nonsteroidal Approaches for Atopic Dermatitis®: A Clinical Update.
Peter Y Ch'en1, Peter A Lio2,3
1From the Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Dermatitis : Contact, Atopic, Occupational, Drug
|February 6, 2024
Summary
Topical corticosteroids (TCSs) are common for atopic dermatitis (AD), but nonsteroidal options are emerging. This study proposes a structured treatment ladder for nonsteroidal therapies to manage AD effectively and address patient concerns.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical corticosteroids (TCSs) are the primary treatment for atopic dermatitis (AD).
- Prolonged TCS use can lead to adverse effects like skin atrophy and patient "corticophobia."
- Emerging nonsteroidal therapies offer alternatives for AD management.
Purpose of the Study:
- To propose a structured treatment ladder and action plan for nonsteroidal therapies in AD management.
- To guide clinicians and patients in selecting appropriate nonsteroidal treatments.
- To facilitate a potential shift towards nonsteroidal approaches for AD.
Main Methods:
- Review of current nonsteroidal treatment options for AD.
- Development of a tiered treatment ladder categorizing therapies for exacerbations and maintenance.
- Consideration of potential adverse effects, both real and perceived.
Main Results:
- A proposed treatment algorithm categorizes nonsteroidal medications.
- The ladder differentiates between therapies for acute flares and long-term maintenance.
- It outlines an escalating approach based on potential adverse effects.
Conclusions:
- A structured nonsteroidal treatment ladder can guide AD management.
- This approach may address patient "corticophobia" and reduce TCS-related side effects.
- The proposed algorithm supports a comprehensive nonsteroidal strategy for AD.
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