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Woodhouse-Sakati syndrome: A review
1Department of Medical and Surgical Sciences, and Advanced Technologies, "G.F. Ingrassia", Azienda Ospedaliera Universitaria "G. Rodolico-San Marco", University of Catania, Catania, Italy.
Abstract:
Neurodegeneration with brain iron accumulation (NBIA) is a rare and inherited spectrum of movement disorders caused by mutations affecting the function of proteins that participate in the homeostasis of tissue metals such as iron or copper and other metabolic pathways, although the precise function of the proteins encoded are not always known. Woodhouse-Sakati Syndrome (WSS) is one of the rarest NBIAs. Patients with WSS are characterized by endocrinological and neurological manifestations and neuroradiological findings. However, diagnostic criteria have not been published yet. This article reviews updates on the genetic, clinical, biological and imaging findings of WSS and provides a practical guide to recognize this extremely rare disorder.
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