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Updated: Jul 4, 2025
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Comparison of methods for intravoxel incoherent motion parameter estimation in the brain from flow-compensated and
Oscar Jalnefjord1,2, Isabella M Björkman-Burtscher3,4
1Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Purpose:
Joint analysis of flow-compensated (FC) and non-flow-compensated (NC) diffusion MRI (dMRI) data has been suggested for increased robustness of intravoxel incoherent motion (IVIM) parameter estimation. For this purpose, a set of methods commonly used or previously found useful for IVIM analysis of dMRI data obtained with conventional diffusion encoding were evaluated in healthy human brain.
Methods:
Five methods for joint IVIM analysis of FC and NC dMRI data were compared: (1) direct non-linear least squares fitting, (2) a segmented fitting algorithm with estimation of the diffusion coefficient from higher b-values of NC data, (3) a Bayesian algorithm with uniform prior distributions, (4) a Bayesian algorithm with spatial prior distributions, and (5) a deep learning-based algorithm. Methods were evaluated on brain dMRI data from healthy subjects and simulated data at multiple noise levels. Bipolar diffusion encoding gradients were used with b-values 0-200 s/mm2 and corresponding flow weighting factors 0-2.35 s/mm for NC data and by design 0 for FC data. Data were acquired twice for repeatability analysis.
Results:
Measurement repeatability as well as estimation bias and variability were at similar levels or better with the Bayesian algorithm with spatial prior distributions and the deep learning-based algorithm for IVIM parameters and , and for the Bayesian algorithm only for , relative to the other methods.
Conclusion:
A Bayesian algorithm with spatial prior distributions is preferable for joint IVIM analysis of FC and NC dMRI data in the healthy human brain, but deep learning-based algorithms appear promising.
