Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells

Area of Science:

• Immunology
• Cardiology
• Exercise Physiology

Background:

• Doxorubicin chemotherapy causes cardiotoxicity, limiting its clinical use.
• Exercise training shows promise in mitigating this cardiotoxicity.
• The specific role of immune cells, particularly B cells, in exercise-mediated protection is not well understood.

Purpose of the Study:

• To investigate the protective role of exercise-derived B cells against doxorubicin-induced cardiotoxicity.
• To determine if B cell activation and antibody secretion are involved in this protective mechanism.

Main Methods:

• Mice received doxorubicin and treadmill exercise.
• Adoptive transfer of exercise-derived B cells into B cell-deficient mice was performed.
• Fc gamma receptor IIB function was blocked in B cell transplants.

Main Results:

• Exercise training improved cardiac function and reduced cardiac damage markers in doxorubicin-treated mice.
• Exercise-derived B cells conferred protection against cardiotoxicity, evidenced by reduced apoptosis and fibrosis.
• Upregulation of Fc gamma receptor IIB on B cells was identified as a key mechanism for exercise-induced protection.

Conclusions:

• Exercise training protects against doxorubicin cardiotoxicity via B cells.
• Upregulation of Fc gamma receptor IIB on B cells by exercise mediates anti-inflammatory effects.
• This study elucidates a novel immune mechanism for exercise-based cardioprotection.