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Updated: Jul 4, 2025
The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
Factors affecting early childhood growth in hypoxic-ischemic encephalopathy treated with hypothermia
Srishti Jayakumar1,2, Vera Joanna Burton3,4, Jamie Perin5
1Kennedy Krieger Institute, Department of Neurology and Developmental Medicine, Baltimore, MD, USA. srishtijayakumar@jhu.edu.
Insights
Early factors like birth head circumference and MRI severity significantly impact growth in infants treated for neonatal hypoxic-ischemic encephalopathy (HIE) with therapeutic hypothermia (TH). These findings are crucial for understanding long-term development in HIE survivors.
Area of Science:
- Neonatal neurology
- Pediatric growth studies
- Hypothermia research
Background:
- Neurological outcomes post-neonatal hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) are well-researched.
- Limited data exists on the growth outcomes of infants with HIE treated with TH.
- This study investigates perinatal factors influencing postnatal growth in this specific population.
Purpose of the Study:
- To examine perinatal characteristics associated with postnatal growth in infants with HIE treated with TH.
- To identify early predictors of growth at 24 months of age.
- To enhance understanding of long-term developmental trajectories in HIE survivors.
Main Methods:
- A convenience cohort of 66 infants with HIE who underwent TH was included.
- Follow-up assessments were conducted at 24 months of age.
- Regression modeling analyzed perinatal anthropometrics, HIE markers, and systemic injury in relation to growth.
Main Results:
- Birth head circumference correlated with weight (p=0.036).
- MRI severity, admission pH, and birth head circumference were associated with height (p=0.043, p=0.015, p=0.043).
- MRI severity and intubation duration predicted head circumference (p=0.038, p<0.001).
Conclusions:
- Significant associations exist between specific early factors and 24-month growth in infants with HIE treated with TH.
- Perinatal characteristics and markers of HIE severity are predictive of growth outcomes.
- These findings highlight the importance of early assessment for predicting long-term growth in HIE survivors.
Introduction:
There is an extensive body of research regarding neurological outcomes following neonatal hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH), with limited data on growth outcomes. We examined perinatal characteristics associated with postnatal growth in this population.
Methods:
Convenience cohort of 66 infants with HIE who underwent TH and participated in follow-up at 24 months of age were included. Regression modeling including perinatal anthropomorphics, markers of HIE, and systemic injury was used to evaluate growth at 24 months.
Results:
Birth head circumference was associated with weight (p = 0.036). MRI severity, pH at admission and birth head circumference were associated with height (p = 0.043, p = 0.015 and p = 0.043 respectively). MRI severity and length of intubation were associated with head circumference (p = 0.038 and p < 0.001 respectively).
Conclusion:
There was a significant association between specific early factors and growth at 24 months among infants with HIE treated with TH.
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