Rethinking heart failure clinical trials: the heart failure collaboratory

Area of Science:

• Cardiology
• Clinical Research
• Health Policy

Background:

• Heart failure (HF) clinical research faces significant infrastructure challenges hindering therapeutic development.
• The Heart Failure Collaboratory (HFC) was established in 2018 to address these obstacles.
• A diverse and inclusive research ecosystem is crucial for advancing HF care.

Purpose of the Study:

• To summarize the successes and initiatives of the Heart Failure Collaboratory (HFC) since its inception.
• To highlight HFC's contributions to improving HF clinical research infrastructure.
• To showcase solutions implemented by HFC to accelerate novel therapy development.

Main Methods:

• The HFC implemented targeted training programs for clinicians involved in HF trials.
• Development and application of novel study designs were central to HFC's strategy.
• Advocacy efforts focused on promoting diversity and inclusivity within the HF research landscape.

Main Results:

• Increased the number of clinicians skilled in conducting complex HF clinical trials.
• Facilitated the adoption of innovative study methodologies.
• Advanced the establishment of a more diverse and inclusive HF research environment.
• Successfully addressed key obstacles in HF clinical research.

Conclusions:

• The Heart Failure Collaboratory (HFC) has made significant strides in enhancing HF clinical research.
• HFC's multifaceted approach, including training and novel designs, is effective in overcoming research barriers.
• Continued focus on inclusivity and innovation is vital for future advancements in heart failure therapies.