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Updated: Jul 4, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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RNA binding proteins in cancer chemotherapeutic drug resistance

Hemanathan Vembuli1,2, Ravi Gor1, Satish Ramalingam1

  • 1Department of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

Frontiers in Cell and Developmental Biology
|February 8, 2024
PubMed

Insights

RNA binding proteins (RBPs) drive chemoresistance in cancer by altering gene expression and promoting cancer stemness. Understanding these RBP-mediated mechanisms is crucial for developing new cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Drug resistance is a significant challenge in cancer treatment, leading to therapeutic failure.
  • RNA binding proteins (RBPs) play critical roles in post-transcriptional gene regulation and are implicated in cancer progression.
  • Aberrant RBP expression is observed in various neoplasms and contributes to cancer stemness and epithelial-to-mesenchymal transition.

Purpose of the Study:

  • To review the mechanisms of chemoresistance mediated by RNA binding proteins (RBPs).
  • To explore the implications of RBP-mediated drug resistance in cancer malignancy.
  • To discuss the correlation between RBPs, noncoding RNAs (ncRNAs), and the inhibition of chemosensitivity.

Main Methods:

  • Literature review of studies on RNA binding proteins and chemoresistance.
  • Analysis of RBP roles in cancer stemness and epithelial-to-mesenchymal transition.
  • Examination of RBP interactions with noncoding RNAs in the context of drug resistance.

Main Results:

  • RBPs are key regulators of gene expression involved in developing chemoresistance.
  • Abnormal RBP expression is linked to cancer progression and poor treatment outcomes.
  • RBPs, in conjunction with ncRNAs, actively suppress chemosensitivity.

Conclusions:

  • Understanding RBP-mediated chemoresistance pathways is vital for advancing cancer treatment.
  • Targeting RBPs and their associated ncRNAs may offer novel therapeutic strategies.
  • Further research into RBP functions can improve cancer diagnosis and therapeutic interventions.
Keywords:
RNA binding proteinsand lncRNAcancercancer stem cellsdrug resistancemiRNA

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