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Nanoparticles for Thrombus Diagnosis and Therapy: Emerging Trends in Thrombus-theranostics
Samridhi1, Aseem Setia1, Abhishesh Kumar Mehata1
1Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi-221005, India.
Insights
This study explores nanomedicines for diagnosing and treating thrombosis, a condition linked to cardiovascular diseases. Nanoparticles offer targeted therapy and imaging for improved thrombosis management.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Research
Background:
- Cardiovascular diseases are primary causes of ischemic stroke, myocardial infarction, and venous thromboembolism.
- Thrombosis is influenced by nutrition, physical activity, and oxidative stress, with complex underlying mechanisms.
- Traditional medicine faces challenges in precise diagnosis and management of thrombosis.
Purpose of the Study:
- To investigate the potential of nanomedicines as theranostic agents for thrombosis.
- To review factors contributing to thrombosis and its consequences.
- To summarize research on thrombus formation and nanoparticle applications in thrombosis.
Main Methods:
- Review of preclinical and clinical studies on thrombus formation.
- Exploration of ultrasound and photoacoustic imaging in thrombosis diagnosis.
- Analysis of nanoparticle-based theranostic approaches for thrombosis.
Main Results:
- Nanomedicines show promise for targeted diagnosis and therapy of thrombosis.
- Non-invasive imaging techniques like ultrasound and photoacoustic imaging are advancing thrombosis management.
- Nanoparticles offer enhanced efficacy and reduced side effects compared to conventional treatments.
Conclusions:
- Nanomedicines represent a significant advancement in theranostic approaches for thrombosis.
- Targeted nanoparticle delivery can improve treatment outcomes for cardiovascular diseases.
- Further research into nanoparticle applications can revolutionize thrombosis diagnosis and therapy.
Abstract:
Cardiovascular disease is one of the chief factors that cause ischemic stroke, myocardial infarction, and venous thromboembolism. The elements that speed up thrombosis include nutritional consumption, physical activity, and oxidative stress. Even though the precise etiology and pathophysiology remain difficult topics that primarily rely on traditional medicine. The diagnosis and management of thrombosis are being developed using discrete non-invasive and non-surgical approaches. One of the emerging promising approach is ultrasound and photoacoustic imaging. The advancement of nanomedicines offers concentrated therapy and diagnosis, imparting efficacy and fewer side effects which is more significant than conventional medicine. This study addresses the potential of nanomedicines as theranostic agents for the treatment of thrombosis. In this article, we describe the factors that lead to thrombosis and its consequences, as well as summarize the findings of studies on thrombus formation in preclinical and clinical models and also provide insights on nanoparticles for thrombus imaging and therapy.
