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Reconstruct Human Retinoblastoma In Vitro
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Orbital Development in Children with Retinoblastoma: An Imaging-Based Study
Shir Forer1, Guy J Ben Simon2,3,4, Gahl Greenberg3,5
1Hadassah Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Seminars in Ophthalmology
|February 8, 2024
Summary
Children treated for Retinoblastoma (Rb) show slower orbital growth compared to healthy eyes. Enucleation further impairs this orbital development, impacting long-term outcomes.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Medical Imaging
Background:
- Retinoblastoma (Rb) is a pediatric eye cancer requiring treatment that may affect ocular development.
- Understanding the long-term impact of Rb treatment on orbital growth is crucial for patient care.
Purpose of the Study:
- To investigate the effects of Retinoblastoma (Rb) treatment on orbital development in children.
- To compare orbital growth in Rb-affected eyes versus healthy eyes.
Main Methods:
- Retrospective case series of 44 children treated for Rb between 2004 and 2020.
- Utilized 3D image processing software to assess orbital volumes and measurements.
- Compared orbital growth differences between Rb-affected and healthy eyes at the last follow-up.
Main Results:
- Orbital volume correlated positively with age only in healthy eyes (p=.03).
- Affected orbits in unilateral Rb cases exhibited smaller horizontal, vertical, and depth dimensions than healthy eyes (p<.05).
- Orbits treated with enucleation showed significantly reduced growth compared to conservative treatment (p=.017).
Conclusions:
- Orbital growth rate is diminished in children treated for Retinoblastoma compared to healthy orbits.
- Enucleation is associated with a negative impact on orbital growth progression.
