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Updated: Jul 4, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis of Substituted Pentafluorosulfanylpyrazoles Under Flow Conditions
Pascal Paquin1,2, Nicolas DeGrâce1, Guillaume Bélanger-Chabot1,2
1CCVC, PROTEO, Département de chimie, Université Laval, 1045 Avenue de la Médecine, Québec, Québec G1V 0A6, Canada.
Abstract:
The development of flow conditions for the synthesis of pentafluorosulfanylpyrazoles is reported. A range of alkyl- and aryl-substituted SF5-alkynes were used in combination with different diazoacetates for this transformation. The corresponding substituted SF5-pyrazoles were obtained in up to 90% yield (average of 74% for 21 examples) as a mixture of isomers (up to 73:27 ratio). Synthetic transformations starting from an SF5-containing pyrazole were also demonstrated.
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