Related Experiment Videos
Steroid receptors in meningiomas
Arquivos De Neuro-Psiquiatria
|December 1, 1985
Summary
Meningiomas frequently contain progesterone receptors (PR), suggesting they are steroid-sensitive tissues. This indicates potential for endocrine therapy in treating recurrent or inoperable meningiomas.
Area of Science:
- Neuro-oncology
- Endocrinology
- Molecular Biology
Background:
- Meningiomas are the most common primary intracranial tumors.
- Steroid hormone receptors play a role in various tumor types.
- The presence and significance of steroid receptors in meningiomas require further investigation.
Purpose of the Study:
- To quantify cytosolic estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid receptors (GR) in human meningiomas.
- To determine the potential role of steroid hormones in meningioma development and treatment.
Main Methods:
- Dextran charcoal coated method was used to evaluate receptor levels.
- Receptor positivity was defined as values >= 10 fMol/mg protein.
- Competition studies were performed to confirm steroid specificity.
Main Results:
- Progesterone receptors (PR) were detected in 90% of meningiomas at high levels (mean 60 +/- 38 fMol/mg prot).
- Glucocorticoid receptors (GR) and androgen receptors (AR) were present in 70% of tumors at moderate levels.
- Estrogen receptors (ER) were found at very low titers in 20% of tumors.
- Higher receptor incidence and titer were observed in female patients.
Conclusions:
- Meningiomas express significant levels of steroid hormone receptors, particularly PR.
- These findings support the hypothesis that meningiomas are target tissues for steroids.
- Endocrine therapy may be a viable treatment option for unresectable or recurrent meningiomas.