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Published on: January 24, 2025
Syphilis Serologies: A Practical Approach for the Primary Care Clinician
Elizabeth A Gilliams1, Zachary Lorenz2, Matthew M Hamill1
1Division of Infectious Diseases, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, 5200 Eastern Avenue, Baltimore, MD 21224, USA.
Abstract:
Syphilis serology interpretation can be challenging even for experienced providers. This article reviews the staging of syphilis and the principles of syphilis serology testing, the algorithms used in diagnosis, and guidance for their use in monitoring the response to treatment. The authors illustrate these principles through a series of clinical scenarios and describe the rationale behind the management approaches.

